Livio Pellizzoni Selected Research

Neurodegenerative Diseases (Neurodegenerative Disease)

1/2022	Neuromuscular denervation and deafferentation but not motor neuron death are disease features in the Smn2B/- mouse model of SMA.
1/2021	Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit.
12/2019	Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy.
11/2018	Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.
1/2018	Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy.
10/2016	Advances in modeling and treating spinal muscular atrophy.
1/2016	A Stem Cell Model of the Motor Circuit Uncouples Motor Neuron Death from Hyperexcitability Induced by SMN Deficiency.
8/2014	SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease.
12/2013	SMN is essential for the biogenesis of U7 small nuclear ribonucleoprotein and 3'-end formation of histone mRNAs.
1/2013	A cell system for phenotypic screening of modifiers of SMN2 gene expression and function.

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Livio Pellizzoni Research Topics

Disease

28	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 02/2023 - 08/2002
12	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 08/2002
3	Atrophy 01/2022 - 10/2016
3	Motor Neuron Disease (Primary Lateral Sclerosis) 08/2014 - 09/2007
2	Neuroinflammatory Diseases 02/2023 - 01/2021
1	Weight Gain 04/2024
1	Weight Loss (Weight Reduction) 03/2007
1	Neuromuscular Diseases (Neuromuscular Disease) 12/2005
1	Spinal Diseases (Disease, Spinal) 03/2002
1	Muscular Atrophy (Muscle Atrophy) 03/2002

Drug/Important Bio-Agent (IBA)

25	Proteins (Proteins, Gene)FDA Link 10/2022 - 03/2002
3	Small Nuclear Ribonucleoproteins (snRNP)IBA 01/2021 - 11/2002
2	nusinersenIBA 02/2023 - 10/2022
2	trichostatin A (A 300)IBA 01/2023 - 03/2007
2	Messenger RNA (mRNA)IBA 01/2022 - 08/2014
1	xylometazoline (stas)IBA 04/2024
1	Tamoxifen FDA LinkGeneric 04/2024
1	Cre recombinaseIBA 04/2024
1	Antisense OligonucleotidesIBA 10/2022
1	Histones (Histone)IBA 01/2022
1	U7 Small Nuclear Ribonucleoprotein (U7 snRNP)IBA 01/2022
1	Butyrates (Butyrate)IBA 05/2016
1	RNA (Ribonucleic Acid)IBA 08/2014
1	2,4-diaminoquinazolineIBA 02/2010
1	RibonucleoproteinsIBA 09/2007
1	theasinensin AIBA 03/2007
1	SMN Complex ProteinsIBA 11/2002

Therapy/Procedure

2	Therapeutics 02/2023 - 10/2022
1	Denervation 01/2022